Endocrine Abstracts

Introduction: In the search for markers of invasiveness of pituitary adenomas, we studied the expression of Ki-67 antigen, TOPO 2A (topoisomerase 2 alpha), AIP (Aryl Hydrocarbon Receptor-Interacting Protein), and VEGF (Vascular Endothelial Growth Factor) in somatotropinomas.Material and methods: We studied retrospectively a group of 31 patients (20 female, 11 male) of mean age 43.3±14.3 years who underwent pituitary tumour surgery. Expression of Ki-...

We evaluated the volume of pituitary adenoma in patients treated with ocreotide LAR (SSLAR) prior to surgery.Materials and methods: Twenty-six patients (22 females and 4 males, mean age 57.5±15.0 years) were treated with SSLAR: 5 patients with microadenoma – during 6 months, and 21 patients with macroadenoma – during 12 months before surgery, as recommended by the Polish Society of Endocrinology. Concentration of hGH and IGF1 was evaluated...

Treatment of acromegalic patients with somatostatin analogues decreases hGH and IGF1 concentrations, improves general and metabolic conditions and decreases morbidity and mortality in these patients. We assessed the efficacy of octreotide LAR (SSLAR) in treating acromegalic patients following non-radical surgery of pituitary adenoma at a single centre.Materials and methods: At our Centre we follow 85 acromegalic patients who underwent surgery, including ...

Background: Somatostatin analogues are used to treat acromegaly patients who, following surgery, have not fulfilled cure criteria (hGH<2,5 ng/ml, IGF-1 below normal range for age and post-OGTT hGH <1,0 ng/ml). We evaluated the efficacy of Sandostatin LAR in managing such patients.Material and method: In our Clinic, 81 acromegaly patients (mean age 51.6±14.4 yrs) were registered over the years 1983-2005. Based on CT i MRI, macroadenoma and mi...

Introduction: As observed clinically, the development of pituitary tumours and the probability of their recurrence after neurosurgery tend to be unpredictable. The aim of this work was to evaluate Ki-67 and nuclear and plasmatic prothymosin alpha indices as potential pathological markers to predict the aggressiveness of pituitary adenomas.Material and methods: Ki-67 and prothymosin alpha indices were determined by immunochemistry in specimens excised fro...

Introduction: During clinical observation the behaviour of pituitary tumours is often unpredictable. The work was aimed at evaluating Ki-67 and pituitary tumour transforming gene (PTTG) indices in pituitary adenomas.Material and methods: The Ki-67 and PTTG indices were determined by immunochemistry in specimens excised from neurosurgically removed pituitary tumours. In fifty two examined patients (30 females and 22 males, mean age 50.5±15.4 years) w...

Introduction: In acromegalic patients the incidence of benign and malignant neoplasms, appears to be higher than that in the standard population. Our aim was to evaluate the incidence of tumours in acromegalic patients treated at our Department.Materials and methods: Over the years 1983–2008, 101 acromegalic patients (mean age 51.8±15.4 years), were diagnosed and treated in our Department. Pituitary macroadenoma and microadenoma were stated in ...

Introduction: Radioiodine treatment of hyperthyroidism of ophthalmopathy (GO) patients may cause or aggravate GO (in some 15%). We evaluated the activity and severity of ophthalmopathy in patients who acquired GO following radioiodine therapy.Materials and methods: Over the years 2003–2005, 1500 hyperthyroid patients were treated with radioiodine at our Clinic. Of these, 50.9% suffered from Graves’ disease. Following their radioiodine treatment...

Background: Primary hyperparathyroidism (HPT) is the most common endocrinopathy in MEN1 and usually its first clinical manifestation. Yet MEN1 is a rare disease, representing only 2–4% of all cases of HTP. We studied the frequency of MEN1 syndrome in HPT patients admitted to our Department.Methods: In a retrospective analysis of 84 suspected HPT patients hospitalized in 1999–2006, case reports of 11 patients with suspected MEN1 were analysed. M...

Goiter frequency (GF) in schoolchildren and urinary iodine concentration (UIC) in an appropriately large population sample are iodine nutrition (IN) best indicators. GF in mildly iodine deficient areas should be assessed ultrasonographically, as palpation sensitivity in such cases is low.Aim: To assess thyroid volume reference values as IN marker in population with recently introduced obligatory iodine prophylaxis (OIP).Material an...